Decoding the Neural Mechanisms to tune the internal GPS

Using a novel virtual reality apparatus developed in-house, a team led by Kavli NDI PIs James Knierim, and Noah Cowan investigated the neural and computational mechanisms that enable the brain to precisely calculate an animal’s location within its environment, essentially, its internal GPS.

The brain region that supports such navigational abilities is also critically involved in the formation and consolidation of long-term memories of specific life events and is one of the first brain regions to show degeneration in Alzheimer’s Disease. By understanding how the brain refines spatial navigation, the group aims to enhance our understanding of memory and neurodegenerative conditions. This study, reported in Nature Neuroscience, is an extension of inaugural Kavli NDI Post Doctoral fellow Manu Madhav’s Kavli NDI Fellowship funded research.  

 

 

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