Kavli NDI Postdoctoral Fellow, Dr. Jonathan Ling, and colleagues developed a computational data mining resource, ASCOT, to determine how novel cell type-specific splicing variants are regulated across the nervous system.
Featured Event
Maximiliano Nigro, PhD, NTNU, Kavli Institute for Systems Neurosciences "Diversity of GABAergic interneurons in the perirhinal cortex"
Cortical inhibitory interneurons powerfully shape information processing in cortical networks. Their wide diversity endows cortical microcircuits with a variety of computational capabilities. The perirhinal cortex has been shown to have a low density of parvalbumin-expressing interneurons (PV-IN), the most abundant inhibitory cell type in the cortex. However, the density and composition of the GABAergic population in perirhinal is still unknown. I used a combination of neuroanatomy, intersectional genetics and in vitro physiology to describe the diversity of GABAergic neurons in the mouse perirhinal cortex. I will show that PV-IN are a minor population in perirhinal cortex, and their density decreases along the rostro-caudal axis. Moreover, a population negative for PV, somatostatin and vasoactive intestinal peptide represents the largest population across the layers of perirhinal cortex. I am using in vitro physiology and intersectional genetics to dissect this peculiar population of interneurons in perirhinal cortex.
Featured Event
Maximiliano Nigro, PhD, NTNU, Kavli Institute for Systems Neurosciences "Diversity of GABAergic interneurons in the perirhinal cortex"
Cortical inhibitory interneurons powerfully shape information processing in cortical networks. Their wide diversity endows cortical microcircuits with a variety of computational capabilities. The perirhinal cortex has been shown to have a low density of parvalbumin-expressing interneurons (PV-IN), the most abundant inhibitory cell type in the cortex. However, the density and composition of the GABAergic population in perirhinal is still unknown. I used a combination of neuroanatomy, intersectional genetics and in vitro physiology to describe the diversity of GABAergic neurons in the mouse perirhinal cortex. I will show that PV-IN are a minor population in perirhinal cortex, and their density decreases along the rostro-caudal axis. Moreover, a population negative for PV, somatostatin and vasoactive intestinal peptide represents the largest population across the layers of perirhinal cortex. I am using in vitro physiology and intersectional genetics to dissect this peculiar population of interneurons in perirhinal cortex.