GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors

Chiu et al. report in Neuron this week that GRASP1 functions in regulating in vivo synapse number, learning-dependent AMPAR synaptic incorporation, synaptic plasticity, and cognition. 

GRASP1 mutations identified from intellectual disability patients show convergent effects on AMPAR recycling as well as structural and functional plasticity. 

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