To allow real-time, minimally invasive study of neuroactivities in vivo, our lab develops Fiber-Optic Neuro-Cellular Interface platforms to image and study the activity of massive numbers of single cells within the peripheral and central nervous system of awake, freely moving animals. This entrepreneurial endeavor between optical engineering and systems neuroscience capitalizes on novel fiber-optic imaging methods and signal processing and applies and adapts those techniques to the imaging and study of the nervous system. The system consists of multiple imaging modalities including reflectance wide field, single-photon fluorescence confocal, and photoacoustic microscopy. The sub-millimeter fiber optic probes can be implanted in multiple sites providing simultaneous imaging and sensing of neuro-activities at different brain sites with high spatiotemporal resolution.