Our group integrates next-generation sequencing techologies with advanced molecular biology techniques to begin to address these broad questions in a variety of specific contexts.

We are particularly interested in the regulatory role of long non-coding RNAs (lncRNAs) in the establishment of cell identity during differentiation. This recently expanded class of regulatory RNA genes represents a foundational shift in how we think about gene regulation, disease pathophysiology, and what it means to be a gene.

We explore these questions in the context of the mammalian brain; an organ system with an incredible diversity of cell types.