Loyal Goff,PHD

Associate Professor of Neuroscience

Specialization: Long Non-coding RNAs in Neuronal and Glial Cell Fate Specification


Johns Hopkins University School of Medicine

733 N. Broadway

MRB 449

Baltimore, MD 21205



Goff Lab

The Goff Lab at Johns Hopkins University School of Medicine studies the establishment of cellular identity during differentiation. How do complex systems reproducibly establish specific cellular subtypes over development? What are the key molecular decisions that affect cell fates? How do these processes go awry during disease?

Our group integrates next-generation sequencing techologies with advanced molecular biology techniques to begin to address these broad questions in a variety of specific contexts.

We are particularly interested in the regulatory role of long non-coding RNAs (lncRNAs) in the establishment of cell identity during differentiation. This recently expanded class of regulatory RNA genes represents a foundational shift in how we think about gene regulation, disease pathophysiology, and what it means to be a gene.

We explore these questions in the context of the mammalian brain; an organ system with an incredible diversity of cell types.


To advance neuroscience discovery by uniting neuroscience, engineering and computational data science to understand the structure and function of the brain.