GRASP1 mutations identified from intellectual disability patients show convergent effects on AMPAR recycling as well as structural and functional plasticity.
GRASP1 Regulates Synaptic Plasticity and Learning through Endosomal Recycling of AMPA Receptors
Chiu et al. report in Neuron this week that GRASP1 functions in regulating in vivo synapse number, learning-dependent AMPAR synaptic incorporation, synaptic plasticity, and cognition.