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To advance neuroscience discovery by uniting neuroscience, engineering and computational data science to understand the structure and function of the brain.

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09/23/2019

Kavli NDI News

The Synaptic Organization of Layer 6: Inhibition redefining cortical microcircuitry

Frandolig et al. show that the neuronal composition and circuit organization differs between two distinct sublayers in layer 6a. 

Featured Event

Tuesday 12/3/2019

Maximiliano Nigro, PhD, NTNU, Kavli Institute for Systems Neurosciences "Diversity of GABAergic interneurons in the perirhinal cortex"

Cortical inhibitory interneurons powerfully shape information processing in cortical networks. Their wide diversity endows cortical microcircuits with a variety of computational capabilities. The perirhinal cortex has been shown to have a low density of parvalbumin-expressing interneurons (PV-IN), the most abundant inhibitory cell type in the cortex. However, the density and composition of the GABAergic population in perirhinal is still unknown. I used a combination of neuroanatomy, intersectional genetics and in vitro physiology to describe the diversity of GABAergic neurons in the mouse perirhinal cortex. I will show that PV-IN are a minor population in perirhinal cortex, and their density decreases along the rostro-caudal axis. Moreover, a population negative for PV, somatostatin and vasoactive intestinal peptide represents the largest population across the layers of perirhinal cortex. I am using in vitro physiology and intersectional genetics to dissect this peculiar population of interneurons in perirhinal cortex.

Featured Event

Tuesday 12/3/2019

Maximiliano Nigro, PhD, NTNU, Kavli Institute for Systems Neurosciences "Diversity of GABAergic interneurons in the perirhinal cortex"

Cortical inhibitory interneurons powerfully shape information processing in cortical networks. Their wide diversity endows cortical microcircuits with a variety of computational capabilities. The perirhinal cortex has been shown to have a low density of parvalbumin-expressing interneurons (PV-IN), the most abundant inhibitory cell type in the cortex. However, the density and composition of the GABAergic population in perirhinal is still unknown. I used a combination of neuroanatomy, intersectional genetics and in vitro physiology to describe the diversity of GABAergic neurons in the mouse perirhinal cortex. I will show that PV-IN are a minor population in perirhinal cortex, and their density decreases along the rostro-caudal axis. Moreover, a population negative for PV, somatostatin and vasoactive intestinal peptide represents the largest population across the layers of perirhinal cortex. I am using in vitro physiology and intersectional genetics to dissect this peculiar population of interneurons in perirhinal cortex.

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