Using a novel phospho-deficient GluA2 Y876F knockin mice, the paper’s lead author, Adeline Yong, showed that phosphorylation of the AMPAR subunit, GluA2, at tyrosine-876 is required for homeostatic synaptic strengthening by dictating GluA2 binding to GRIP1, a scaffolding protein crucial for synaptic upscaling. This finding provides an understanding of the mechanism through which a neuron can maintain a range of synaptic signaling whilst not compromising its responsiveness to subsequent synaptic activity. Read the full article here.
Novel biochemical regulation of AMPARs for homeostatic synaptic plasticity
The Kavli NDI lab of Dr. Richard Huganir published a paper in PNAS which found a biochemical regulation of AMPARs is specific to homeostatic synaptic plasticity while sparing Hebbian plasticity mechanisms.