What is the functional and anatomic relationship between Reck and Gpr124 loss-of-function defects in the CNS vasculature? What are the functional relationships between Reck and Norrin pathways? Are there defined domains of Reck and Gpr124 that interact physically and functionally? Does signaling—and Wnt specificity—involve a multi-protein complex of ligand, receptor, and co-receptor, together with Gpr124 and Reck?
For answers to these question, access the article "Reck and Gpr124 Are Essential Receptor Cofactors for Wnt7a/Wnt7b-specific Signaling in Mammalina CNS Angiogenesis and Blood-Brain Barrier Regulation" by Cho et al., published in Neuron.